CDC 2019-nCoV Laboratory Test Kit.jpg
The U.S. CDC's COVID-19 laboratory test kit

COVID-19 testing can identify the SARS-CoV-2 virus and includes methods that detect the presence of the virus itself (RT-PCR, isothermal nucleic acid amplification, antigen) and those that detect antibodies produced in response to infection. Detection of antibodies (serological tests) can be used both for diagnosis and for population surveillance. Antibody tests show how many people have had the disease, including those whose symptoms were minor or who were asymptomatic, but may not find antibodies in someone with a current COVID-19 infection since antibodies may not show up for weeks.[1] An accurate mortality rate of the disease and the level of herd immunity in the population can be determined from the results of this test. However, the duration and effectiveness of this immune response are still unclear.[2]

Due to limited testing, as of March 2020 no countries had reliable data on the prevalence of the virus in their population.[3] As of 24 May, countries that publicised their testing data have typically performed many tests equal to 2.6 percent of their population, and no country has tested samples equal to more than 17.3% of its population.[4] There are variations in how much testing has been done across countries.[5] This variability is also likely to be affecting reported case fatality rates, which have probably been overestimated in many countries, due to sampling bias.[6][7][8]

Test methods

Explanation of the underlying pathophysiology pertaining to diagnosis of COVID-19[9]

There are two broad categories of test: a viral test for a current infection, or an antibody test for the past presence of the virus.[10] The CDC does not currently recommend testing for COVID-19 using a CT scan or looking for low oxygen levels.

Current infection

Polymerase chain reaction

Polymerase chain reaction (PCR) is a process that causes a very small well-defined segment of DNA to be amplified, or multiplied many hundreds of thousands of times, so there is enough of it to be detected and analyzed. Viruses such as SARS-CoV-2 do not contain DNA but only RNA.[11] When a respiratory sample is collected from the person being tested it is treated with certain chemicals[12][11] which break down extraneous substances and allow the RNA to be removed from the sample and tested. Reverse transcription polymerase chain reaction (RT-PCR) is a technique that first uses reverse transcription to convert the extracted RNA into DNA and then uses PCR to amplify a piece of the resulting DNA, creating enough to be examined in order to determine if it matches the genetic code of SARS-CoV-2.[11] Real-time PCR (qPCR)[13] provides advantages during the PCR portion of this process, including automating it and enabling high-throughput and more reliable instrumentation, and has become the preferred method.[14][15] Altogether, the combined technique has been described as real-time RT-PCR[16] or quantitative RT-PCR[17] and is sometimes abbreviated qRT-PCR[18] or rRT-PCR[19] or RT-qPCR,[20] although sometimes just RT-PCR or PCR is used as an abbreviation. The Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines propose that the term RT-qPCR be used,[21] but not all authors adhere to this. The test can be done on respiratory samples obtained by various methods, including a nasopharyngeal swab or sputum sample,[22] as well as on saliva.[23] Drosten et al. remarked that for 2003 SARS, "from a diagnostic point of view, it is important to note that nasal and throat swabs seem less suitable for diagnosis, since these materials contain considerably less viral RNA than sputum, and the virus may escape detection if only these materials are tested."[24] Results are generally available from within a few hours to two days.[25]

When testing an infected person the likelihood of detecting the virus depends on how much time has passed since the person was infected. According to Christian Drosten the RT-PCR test performed with throat swabs is reliable only in the first week of the disease. Later on the virus can disappear in the throat while it continues to multiply in the lungs. For infected people tested in the second week, alternatively sample material can then be taken from the deep airways by suction catheter, or coughed up material (sputum) can be used.[26]

Saliva has been shown to be a common and transient medium for virus transmission[27] and results provided to the FDA suggest that testing saliva may be as effective as nasal and throat swabs.[23] The FDA has granted Emergency Use Authorization for a test that collects saliva instead of using the traditional nasal swab.[28] It is believed this will reduce the risk for health care professionals,[29] will be much more comfortable for the patient,[28] and will enable quarantined people to collect their own samples more efficiently.[29] According to some experts it is too early to know the operating characteristics of the saliva test, and whether it will prove to be as sensitive as the nasopharyngeal swab test.[30][27] Some studies suggest that the diagnostic value of saliva depends on how saliva specimens are collected (from deep throat, from oral cavity, or from salivary glands).[27] A recent test conducted by the Yale University School of Public Health found that saliva yielded greater detection sensitivity and consistency throughout the course of infection when compared with samples taken with nasopharyngeal swabs.[31][32]

Isothermal amplification assays

There are a number of isothermal nucleic acid amplification methods that, just like PCR, amplify a piece of the virus's genome, but are faster than PCR because they don't involve repeated cycles of heating and cooling the sample. These tests typically detect the amplified virus sequences using fluorescent tags, which have to be read out with specialized machines. In one new development, the CRISPR gene editing technology was modified to detect the viral sequences instead: if the modified CRISPR enzyme attaches to the sequence, it releases a signal which colors a paper strip. The researchers expect the resulting test to be cheap and easy to use in patient-care settings.[33][34]

Antigen

An antigen is the part of a pathogen that elicits an immune response. The antigen tests look for proteins from the surface of the virus. In the case of a coronavirus, these are usually proteins from the surface spikes, and a nasal swab is used to collect samples.[35] One of the difficulties has been finding a protein target unique to SARS-CoV-2.[36]

Antigen tests are seen as one way to scale up testing to levels necessary to detect acute infection on the scale required.[35] Isothermal nucleic acid amplification tests, can process only one sample at a time per machine. RT-PCR tests are accurate but it takes too much time, energy and trained personnel to run the tests.[35] "There will never be the ability on a [PCR] test to do 300 million tests a day or to test everybody before they go to work or to school," Deborah Birx, head of the White House Coronavirus Task Force, said on April 17. "But there might be with the antigen test."[37]

An antigen test works by taking a nasal swab from a patient and exposing that to paper strips containing artificial antibodies designed to bind to coronavirus antigens. Any antigens that are present will bind to the strips and give a visual readout. The process takes less than 30 minutes, can deliver results on the spot, and does not require expensive equipment or extensive training.[35]

In respiratory viruses often there is not enough of the antigen material present in the nasal swab to be detectable.[36] This would especially be true with people who are asymptomatic and who have very little if any nasal discharge. Unlike the RT-PCR test, which amplifies very small amounts of genetic material so there is enough to detect, there is no amplification of viral proteins in an antigen test.[35][38] According to the World Health Organization (WHO) the sensitivity of similar antigen tests for respiratory diseases like the flu ranges between 34% and 80%. "Based on this information, half or more of COVID-19 infected patients might be missed by such tests, depending on the group of patients tested," the WHO said. Many scientists doubt whether an antigen test can be made reliable enough in time to be useful against COVID-19.[38] According to the FDA, positive results from antigen tests are highly accurate, but there is a higher chance of false negatives, so negative results do not rule out infection. Therefore, negative results from an antigen test may need to be confirmed with a PCR test.[39]

Medical imaging

Chest CT scans and chest x-rays are not recommended for diagnosing COVID-19. Radiologic findings in COVID-19 are not specific.[40][41] Typical features on CT initially include bilateral multilobar ground-glass opacities with a peripheral or posterior distribution.[41] Subpleural dominance, crazy paving, and consolidation may develop as the disease evolves.[41][42]

Past infection

Machine used to analyze blood samples
Table showing amounts of IgG and IgM antibodies detected in sample
Left: Automated analyzer for immunoassays, used, for example, to find SARS-CoV-2 antibodies. Right: Example of quantitative results for SARS-CoV-2 antibody test.

Serology tests rely on drawn blood, not a nasal or throat swab, and can identify people who were infected and have already recovered from COVID-19, including those who did not know they had been infected.[43] As of April 2020, most serology tests were in the research stage of development.[44]

Part of the immune response to infection is the production of antibodies including IgM and IgG. According to the FDA, IgM antibodies to SARS-CoV-2 are generally detectable in blood several days after initial infection, although levels over the course of infection are not well characterized.[45] IgG antibodies to SARS-CoV-2 generally become detectable 10–14 days after infection although they may be detected earlier, and normally peak around 28 days after the onset of infection.[46][47] Since antibodies are slow to present they are not the best markers of acute infection, but as they may persist in the bloodstream for many years they are ideal for detecting historic infections.[35]

Antibody tests can be used to determine the percentage of a population that have contracted the disease and are therefore presumably immune. However, it is still not clear how broad and how long and how effective this immune response is.[2][48] As of April 2020 "[s]ome countries are considering issuing so-called immunity passports or risk-free certificates to people who have antibodies against Covid-19, enabling them to travel or return to work assuming that they are protected against reinfection."[49] However, according to the World Health Organization as of 24 April 2020, "There is currently no evidence that people who have recovered from COVID-19 and have antibodies are protected from a second infection."[50] One of the reasons for the uncertainty is that most, if not all, of the current COVID-19 antibody testing done at large scale is for detection of binding antibodies only and does not measure neutralizing antibodies.[51][52][53] A neutralizing antibody (NAb) is an antibody that defends a cell from a pathogen or infectious particle by neutralizing any effect it has biologically. Neutralization renders the particle no longer infectious or pathogenic.[54] A binding antibody will bind to the pathogen but the pathogen remains infective; the purpose can be to flag the pathogen for destruction by the immune system.[55] It may even enhance infectivity by interacting with receptors on macrophages.[56] Since most COVID-19 antibody tests will return a positive result if they find only binding antibodies these tests cannot indicate that the person being tested has generated any NAbs which would give him or her protection against re-infection.[52][53]

It is normally expected that if binding antibodies are detected the person also has generated NAbs[53] and for many viral diseases total antibody responses correlate somewhat with NAb responses[57] but this is not yet known for COVID-19. A study of 175 people in China who had recovered from COVID‑19 and had mild symptoms reported that 10 individuals had produced no detectable NAbs at the time of discharge, nor did they develop NAbs thereafter. How these patients recovered without the help of NAbs and whether they were at risk of re-infection of SARS-CoV-2 was left for further exploration.[52][58] An additional source of uncertainty is that even if NAbs are present, several viruses, such as HIV, have evolved mechanisms to evade NAb responses. While this needs to be examined in the context of COVID-19 infection, past experiences with viral infection, in general, argue that in most recovered patients NAb level is a good indicator of protective immunity.[51]

The issue of NAbs was implicated when five sailors from the USS Theodore Roosevelt (CVN-71) who tested positive went through two weeks of isolation, then tested negative twice, and thereafter again tested positive.[59] IgG antibodies normally peak around 28 days after the onset of infection[46] and the time frame of these events is not available.

It is presumed that once a person has been infected his or her chance of getting a second infection two to three months later is low, but how long that protective immunity might last is not known.[52] One study determined that reinfection at 29 days post-infection could not occur in SARS-CoV-2 infected rhesus macaques.[60] Studies have indicated that NAbs to the original SARS virus (the predecessor to the current SARS-CoV-2) can remain active in most people for two years[61] and are gone after six years.[62] Nevertheless, memory cells including Memory B cells and Memory T cells[63] can last much longer and may have the ability to greatly lessen the severity of a reinfection.[62]

Infectivity

United States Centers for Disease Control and Prevention (CDC) updated the following information and recommendation in a "Decision Memo" on 3 May.[64] At this time, data are limited regarding how long after infection people continue to shed infectious SARV-CoV-2 RNA, and can therefore still infect others. Key findings are summarized here.

  1. Viral burden measured in upper respiratory specimens declines after onset of illness.[65]
  2. At this time, replication-competent virus has not been successfully cultured more than nine days after onset of illness. The statistically estimated likelihood of recovering replication-competent virus approaches zero by 10 days.[66]
  3. As the likelihood of isolating replication-competent virus decreases, anti-SARS-CoV-2 IgM and IgG can be detected in an increasing number of persons recovering from infection.[67]
  4. Attempts to culture virus from upper respiratory specimens have been largely unsuccessful when viral burden is in low but detectable ranges (i.e., Ct values higher than 33-35)[64]
  5. Following recovery from clinical illness, many patients no longer have detectable viral RNA in upper respiratory specimens. Among those who continue to have detectable RNA, concentrations of detectable RNA three days following recovery are generally in the range at which replication-competent virus has not been reliably isolated by CDC.[68]
  6. No clear correlation has been described between length of illness and duration of post-recovery shedding of detectable viral RNA in upper respiratory specimens.[69]
  7. Infectious virus has not been cultured from urine or reliably cultured from feces;[70] these potential sources pose minimal if any risk of transmitting infection and any risk can be sufficiently mitigated by good hand hygiene.

For an emerging pathogen like SARS-CoV-2, the patterns and duration of illness and infectivity have not been fully described. However, available data indicate that shedding of SARS-CoV-2 RNA in upper respiratory specimens declines after onset of symptoms. At 10 days after illness onset, recovery of replication-competent virus in viral culture (as a proxy of the presence of infectious virus) is decreased and approaches zero. Although persons may produce PCR-positive specimens for up to six weeks,[71] it remains unknown whether these PCR-positive samples represent the presence of infectious virus. After clinical recovery, many patients do not continue to shed SARS-CoV-2 viral RNA. Among recovered patients with detectable RNA in upper respiratory specimens, concentrations of RNA after three days are generally in ranges where virus has not been reliably cultured by CDC. These data have been generated from adults across a variety of age groups and with varying severity of illness. Data from children and infants are not presently available.[64]

Minimum testing necessary

According to epidemiologists, as lockdown measures are being relaxed effective containment of the pandemic in the United States will not be possible until all infected people can be rapidly located and isolated before they have a chance to infect others, and this will require widespread testing of people before they even begin to show symptoms.[72] The contagiousness of a disease is indicated by the basic reproduction number (R0) of the disease. The R0 (pronounced "R naught")[73] of SARS-CoV-2 in general is thought to be from 2.2 to 2.5,[74][75] meaning that in a population where all individuals are susceptible to infection, each infected person is expected to infect 2.2 to 2.5 other people.[76] However this can vary from location to location.[77] In New York state the R0 is 3.4 to 3.8.[78] One factor that increases the difficulty of blocking the spread of SARS-CoV-2 is that, on average, an infected person begins showing symptoms five days after becoming infected (the "incubation period") and begins infecting others two to three days before symptoms appear.[74][79] According to a recent study, an estimated 44% of viral transmissions occur within this period.[74][80] In addition to this, a significant number of infected people never show symptoms but are nevertheless contagious.[80][75] Therefore, if transmission of this disease is to be blocked effectively, people must be tested and isolated before they begin to show symptoms.

According to Harvard's Global Health Institute, the U.S. should be doing more than 900,000 tests per day as a country.[81][82] Other organizations have given varying estimates of up to 23 million tests per day.[83][84][85][86] For the week ending 17 May there were an average of 363,000 tests per day in the United States.[87] According to the World Health Organization if more than 10% of the tests given are coming back positive then not enough testing is being done.[88] How close each state is to the minimum number of tests it should be performing according to the Harvard Global Health Institute estimate, and to the 10% target, as of 6 May, is shown here.

According to some epidemiologists, this huge increase in testing will require that states build a much-expanded testing infrastructure. This would include mobile testing programs and neighborhood testing sites, allowing special attention to be given to high-risk groups such as those in long term-care facilities; the homeless and those working in shelters; employees in high-density workplaces; and anyone who has had close contact with a known COVID-19 patient. Such people would be tested every five days.[72]

Paul Romer believes the U.S. already has the technical capacity to scale up to 20 million tests per day, which is his estimate as to the number that will be necessary to fully remobilize the economy.[84] According to the Edmond J. Safra Center for Ethics this capacity can be available by late July.[89] Romer points to the Single-molecule real-time sequencing equipment from Pacific Biosciences, which is in use in 20 laboratories in the U.S.[90][84] and to the Ion Torrent Next-Generation Sequencing equipment from ThermoFisher Scientific, which is in use in 16 laboratories in the U.S.[91][84] According to Romer, "Recent research papers suggest that any one of these has the potential to scale up to millions of tests per day." He adds that this plan would also require removing restrictive regulatory hurdles managed by the FDA. Romer estimates that this amount of testing would require that the Congress allocate $100 billion to generate a revenue stream for labs to rapidly expand testing capability.[84]

Also according to Paul Romer, even a relatively inaccurate test, if administered frequently enough, can produce successful results. He ran simulations in which 7% of the population is tested every day with a test that has a 20% false negative rate (20% of the people who are actually infected will get a negative test result because of a bad swab or a very low level of virus in the early stage of infection) and a 1% false positive rate. The average person would be tested roughly every two weeks and those who tested positive would go into quarantine. Romer concluded that the fraction of the population that is currently infected (known as the attack rate) peaks early, reaching roughly 8% of the population in about thirty days and then gradually declines, in most runs reaching zero at 500 days, with the cumulative fraction of the population that is ultimately infected kept below 20%. Romer adds that these results are indicative, not predictive about the true behavior of the spread of the virus, and should not be taken as being something one can rely on.[92]

Approaches to testing

A sample collection kiosk for COVID-19 testing in India
Timeline of total number of tests in different countries[93]
A temporary drive-in testing site for COVID-19 set up with tents in a parking lot

After issues with testing accuracy and capacity during January and February, the United States was conducting an average of 363,000 tests per day for the week ending 17 May.[87][94] In comparison, several European countries have been conducting more daily tests per capita than the United States.[95][96] Three European countries are aiming to conduct 100,000 tests per day—Germany by mid-April, the United Kingdom by the end of April and France by the end of June. Germany has a large medical diagnostics industry, with more than a hundred testing labs that provided the technology and infrastructure to enable rapid increases in testing. The UK sought to diversify its life sciences companies into diagnostics to scale up testing capacity.[97]

In Germany, the National Association of Statutory Health Insurance Physicians said on 2 March that it had a capacity for about 12,000 tests per day in the ambulatory setting and 10,700 had been tested in the prior week. Costs are borne by the health insurance when the test is ordered by a physician.[98] According to the president of the Robert Koch Institute, Germany has an overall capacity for 160,000 tests per week.[99] As of 19 March drive-in tests were offered in several large cities.[100] As of 26 March, the total number of tests performed in Germany was unknown, because only positive results are reported. Health minister Jens Spahn estimated 200,000 tests per week.[101] A first lab survey revealed that as of the end of March a total of at least 483,295 samples were tested and 33,491 samples (6.9%) tested positive for SARS-CoV-2.[102]

By the start of April, the United Kingdom was delivering around 10,000 swab tests per day. It set a target for 100,000 per day by the end of April, eventually rising to 250,000 tests per day.[97] The British NHS has announced that it is piloting a scheme to test suspected cases at home, which removes the risk of a patient infecting others if they come to a hospital or having to disinfect an ambulance if one is used.[103]

In drive-through testing for COVID‑19 for suspected cases, a healthcare professional takes sample using appropriate precautions.[104][105] Drive-through centers have helped South Korea do some of the fastest, most-extensive testing of any country.[106] Hong Kong has set up a scheme where suspected patients can stay home, "[the] emergency department will give a specimen tube to the patient", they spit into it, send it back and get a test result a while after.[107]

In Israel, researchers at Technion and Rambam Hospital developed and tested a method for testing samples from 64 patients simultaneously, by pooling the samples and only testing further if the combined sample is found to be positive.[108][109][110] Pool testing was then adopted in Israel, Germany, South Korea,[111] and Nebraska,[112] and the Indian states Uttar Pradesh,[113] West Bengal,[114] Punjab,[115] Chhattisgarh,[116] and Maharashtra.[117]

In Wuhan a makeshift 2000-sq-meter emergency detection laboratory named "Huo-Yan" (Chinese: 火眼, "Fire Eye") was opened on 5 February 2020 by BGI,[118][119] which can process more than 10,000 samples a day.[120][119] With the construction overseen by BGI-founder Wang Jian and taking 5-days,[121] modelling has show cases in Hubei would have been 47% higher and the corresponding cost of tackling the quarantine would have doubled if this testing capacity had not come into operation.[citation needed] The Wuhan Laboratory has been promptly followed by Huo-Yan labs in Shenzhen, Tianjin, Beijing, and Shanghai, in a total of 12 cities across China. By 4 March the daily throughput totals were 50,000 tests per day.[122]

Open source, multiplexed designs released by Origami Assays have been released that can test as many as 1122 patient samples for COVID-19 using only 93 assays.[123] These balanced designs can be run in small laboratories without the need for robotic liquid handlers.

By March, shortages and insufficient amounts of reagent has become a bottleneck for mass testing in the EU and UK[124] and the U.S.[125][126] This has led some authors to explore sample preparation protocols that involve heating samples at 98 °C (208 °F) for five minutes to release RNA genomes for further testing.[127][128]

On 31 March it was announced United Arab Emirates was now testing more of its population for Coronavirus per head than any other country, and was on track to scale up the level of testing to reach the bulk of the population.[129] This was through a combination of drive-through capability, and purchasing a population-scale mass-throughput laboratory from Group 42 and BGI (based on their "Huo-Yan" emergency detection laboratories in China). Constructed in 14 days, the lab is capable of conducting tens of thousands RT-PCR tests per day and is the first in the world of this scale to be operational outside of China.[130]

On 8 April 2020, In India, the Supreme Court of India ruled that private labs should be reimbursed at the appropriate time for COVID-19 tests[131] However private labs have stated that they are unable to scale up the testing because of the price cap put on the testing and labs being forced to make advance payment to suppliers while they receive deferred payment from hospitals.[132]

University of California San Francisco conducted PCR tests of 1,845 people in Bolinas, California on April 20–24, almost the entire town. No active infections were detected. Antibody testing was also performed but the results are not yet available.[133]

In a Stanford study led by Jay Bhattacharya, an antibody test was conducted on 5,603 major league baseball employees and 0.7% tested positive, showing they had been infected in the past. 70% of those who tested positive had had no symptoms.[134][135][136]

Production and volume

Number of tests done per day in the United States.
Blue: CDC lab
Orange: Public health lab
Gray: Data incomplete due to reporting lag
Not shown: Testing at private labs; total exceeded 100,000 per day by 27 March.[137]

Different testing recipes targeting different parts of the coronavirus genetic profile were developed in China, France, Germany, Hong Kong, Japan, the United Kingdom, and the United States. The World Health Organization adopted the German recipe for manufacturing kits sent to low-income countries without the resources to develop their own. The German recipe was published on 17 January 2020; the protocol developed by the United States Centers for Disease Control and Prevention (CDC) was not available until 28 January, delaying available tests in the U.S.[138]

China[139] and the United States[140] had problems with the reliability of test kits early in the outbreak, and these countries and Australia[141] were unable to supply enough kits to satisfy demand and recommendations for testing by health experts. In contrast, experts say South Korea's broad availability of testing helped reduce the spread of the novel coronavirus. Testing capacity, largely in private sector labs, was built up over several years by the South Korean government.[142] On 16 March, the World Health Organization called for ramping up the testing programmes as the best way to slow the advance of COVID‑19 pandemic.[143][144]

High demand for testing due to wide spread of the virus caused backlogs of hundreds of thousands of tests at private U.S. labs, and supplies of swabs and chemical reagents became strained.[145]

Available tests

PCR based

All tests that have received an Emergency Use Authorization are listed at the FDA website.

Some community-based testing sites in the United States are listed at the HHS website. Additional testing sites can be found here as well as at state and local health department websites. Nearby testing sites can also be located on Apple maps[146] and Google maps[147] by searching for "COVID-19 test".

When scientists from China first released information on the COVID‑19 viral genome on 11 January 2020, the Malaysian Institute for Medical Research (IMR) successfully produced the "primers and probes" specific to SARS-CoV-2 on the very same day. The IMR's laboratory in Kuala Lumpur had initiated early preparedness by setting up reagents to detect coronavirus using the RT-PCR method.[148] The WHO reagent sequence (primers and probes) released several days later was very similar to that produced in the IMR's laboratory, which was used to diagnose Malaysia's first COVID‑19 patient on 24 January 2020.[149]

Public Health England developed a test by 10 January,[150] using real-time RT-PCR (RdRp gene) assay based on oral swabs.[151] The test detected the presence of any type of coronavirus including specifically identifying SARS-CoV-2. It was rolled out to twelve laboratories across the United Kingdom on 10 February.[152] Another early PCR test was developed by Charité in Berlin, working with academic collaborators in Europe and Hong Kong, and published on 23 January. It used rtRT-PCR, and formed the basis of 250,000 kits for distribution by the World Health Organization (WHO).[153] The South Korean company Kogenebiotech developed a clinical grade, PCR-based SARS-CoV-2 detection kit (PowerChek Coronavirus) approved by Korea Centers for Disease Control and Prevention (KCDC) on 4 February 2020.[154] It looks for the "E" gene shared by all beta coronaviruses, and the RdRp gene specific to SARS-CoV-2.[155]

In China, BGI Group was one of the first companies to receive emergency use approval from China's National Medical Products Administration for a PCR-based SARS-CoV-2 detection kit.[156]

In the United States, the CDC distributed its SARS-CoV-2 Real Time PCR Diagnostic Panel to public health labs through the International Reagent Resource.[157] One of three genetic tests in older versions of the test kits caused inconclusive results due to faulty reagents, and a bottleneck of testing at the CDC in Atlanta; this resulted in an average of fewer than 100 samples a day being successfully processed throughout the whole of February 2020. Tests using two components were not determined to be reliable until 28 February 2020, and it was not until then that state and local laboratories were permitted to begin testing.[158] The test was approved by the FDA under an EUA.[citation needed]

U.S. commercial labs began testing in early March 2020. As of 5 March LabCorp announced nationwide availability of COVID‑19 testing based on RT-PCR.[159] Quest Diagnostics similarly made nationwide COVID‑19 testing available as of 9 March.[160]

In Russia, the first COVID‑19 test was developed by the State Research Center of Virology and Biotechnology VECTOR, production began on January 24.[161] On 11 February 2020 the test was approved by the Federal Service for Surveillance in Healthcare.[162]

On 12 March 2020, Mayo Clinic was reported to have developed a test to detect COVID‑19 infection.[163]

On 18 March 2020, the FDA issued EUA to Abbott Laboratories[164] for a test on Abbott's m2000 system; the FDA had previously issued similar authorization to Hologic,[165] LabCorp,[164] and Thermo Fisher Scientific.[166] On 21 March 2020, Cepheid similarly received an EUA from the FDA for a test that takes about 45 minutes on its GeneXpert system; the same system that runs the GeneXpert MTB/RIF.[167][168]

On 13 April, Health Canada approved a test from Spartan Bioscience. Institutions may "test patients" with a handheld DNA analyzer "and receive results without having to send samples away to a [central] lab".[169][170]

Isothermal nucleic amplification

U.S. President Donald Trump displays a COVID-19 testing kit from Abbott Laboratories in March 2020.

On 27 March 2020, the FDA issued an Emergency Use Authorization for a test by Abbott Laboratories, called ID NOW COVID-19, that uses isothermal nucleic acid amplification technology instead of PCR.[171] The assay amplifies a unique region of the virus's RdRp gene; the resulting copies are then detected with "fluorescently-labeled molecular beacons".[172] The test kit uses the company's "toaster-size" ID NOW device which costs $12,000-$15,000.[173] The device can be used in laboratories or in patient care settings, and provides results in 13 minutes or less.[172] There are currently about 18,000 ID NOW devices in the U.S. and Abbott expects to ramp up manufacturing to deliver 50,000 ID NOW COVID-19 test kits per day.[174]

All visitors to U.S. President Donald Trump are required to undergo the test on site at the White House.[175]

Antigen tests

On 8 May 2020, the FDA granted the first Emergency Use Authorization for a COVID-19 antigen test: "Sofia 2 SARS Antigen FIA" by Quidel Corp.[176][39] It is a lateral flow test which uses monoclonal antibodies to detect the virus's nucleocapsid (N) protein.[177] The result of the test is read out by the company's Sofia 2 device using immunofluorescence.[177] The test, simpler and cheaper but less accurate than available PCR tests, can be used in laboratories or in patient care settings and gives results in 15 minutes.[176] A negative test result may occur if the level of antigen in a sample is below the detection limit of the test and should be confirmed with an RT-PCR test.[177]

Serology tests

As of 4 May, eleven tests had been approved for diagnosis in the United States, all under FDA Emergency Use Authorization (EUA).[178] The tests are listed and described at the Johns Hopkins Center for Health Security. Other tests have been approved in other countries.[179]

In the United States, as of 28 April, Quest Diagnostics made a COVID-19 antibody test available for purchase to the general public through the QuestDirect service. Cost of the test is approximately US$130. The test requires the individual to visit a Quest Diagnostics location for a blood draw. Results are available days later.[180] An antibody test is also available through LabCorp.

A number of countries are beginning large scale surveys of their populations using these tests.[181][182] A study in California conducted antibody testing in one county and estimated that the number of coronaviruses cases was between 2.5 and 4.2% of the population, or 50 to 85 times higher than the number of confirmed cases.[183][184]

In late March 2020, a number of companies received European approvals for their test kits. The testing capacity is several hundred samples within hours. The antibodies are usually detectable 14 days after the onset of the infection.[185]

In May 2020, Roche received Emergency Use Authorization from the U.S. Food and Drug Administration (FDA) for a selective ELISA serology test to detect COVID-19 antibodies.[186][187][188][189]

WHO Emergency Use Listing

Diagnostic tests accepted by the WHO for procurement
Date listed Product name Manufacturer
3 April 2020 Cobas SARS-CoV-2 qualitative assay for use on the cobas 6800/8800 Systems Roche Molecular Systems
7 April 2020 Coronavirus (COVID-19) genesig rtPCR assay Primerdesign
9 April 2020 Abbott Realtime SARS-CoV-2[190] Abbott Molecular
24 April 2020 PerkinElmer SARS-CoV-2 Real-time RT-PCR Assay[190] SYM-BIO LiveScience

As of 7 April 2020, the WHO had accepted two diagnostic tests for procurement under the Emergency Use Listing procedure (EUL) for use during the COVID‑19 pandemic, in order to increase access to quality-assured, accurate tests for the disease.[191] Both in vitro diagnostics, the tests are genesig Real-Time PCR Coronavirus (COVID‑19) manufactured by Primerdesign, and cobas SARS-CoV-2 Qualitative assay for use on the cobas® 6800/8800 Systems by Roche Molecular Systems. Approval means these tests can also be supplied by the United Nations and other procurement agencies supporting the COVID‑19 response.[clarification needed]

Testing accuracy

The location of sample collection impact on sensitivity for COVID-19 in 205 Wuhan patients[192]
Samples from ... Positive rate
Bronchoalveolar lavage fluid specimens 93% (n=14)
Sputum 72% (n=75)
Nasal swabs 63% (n=5)
Fibrobronchoscope brush biopsy 46% (6/13)
Pharyngeal swabs 32% (n=126)
Feces 29% (n=44)
Blood 1% (n=3)

PCR-based test

Detection of SARS-CoV-2 by nasal swab over six weeks in patients who experienced mild to moderate illness

RT-PCR is considered the gold standard of diagnosis for COVID-19 and other viruses.[139] Although it has high sensitivity and specificity in a laboratory setting, in one study the sensitivity dropped to 66-88% clinically.[193] Most experts believe improper sample collection, exemplified by failure to acquire enough sample and failure to insert a swab deep into the nose, are to blame for the low clinical sensitivity. The time course of infection also affects the accuracy, for being too late or too early to be tested can lead to a viral load that is too low to be detected, whereas RNA breakdown due to improper storage for too long time could also lead to wrong results.[194] In one study a positive test result was highest at week one (100%), followed by 89.3%, 66.1%, 32.1%, 5.4% and zero by week six.[195][196]

Early in March 2020, China has been reporting the problems with accuracy in their test kits.[139] A paper published in JAMA researched the RT-PCR sensitivity for COVID-19 in 1070 samples from 205 Wuhan patients, shows a varied sensitivity according to the methods and location of sample collection, where samples from bronchoalveolar lavage fluid specimens tested with the highest sensitivity for COVID-19.[192] The authors argued that CT scan shows a higher sensitivity for testing for COVID-19.[197] Spain purchased test kits from Chinese firm Shenzhen Bioeasy Biotechnology Co Ltd, but found that results were inaccurate. The firm explained that the incorrect results may be a result of a failure to collect samples or use the kits correctly. The Spanish ministry said it will withdraw the kits that returned incorrect results, and would replace them with a different testing kit provided by Shenzhen Bioeasy.[198]

Different test kits also shows inconsistent sensitivity. According to a Dutch CDC-led laboratory investigation comparing 7 PCR test kits from different countries,[199] test kits made by BGI from Shenzhen, China, shows the highest sensitivity compared to the test kits from other countries.[200] The test kits with the highest sensitivity, including those from R-Biopharm AG, BGI, KH Medical, and Seegene, are recommended to diagnose people with low viral loads, while all the other test kits are still satisfying when used for those routine diagnostics of symptomatic patients, according to the research.[199] In the United States, the test kits developed by the CDC had "flaws;" the government then removed the bureaucratic barriers that had prevented private testing.[140]

Isothermal nucleic amplification test

In a study conducted by the Cleveland Clinic, the ID NOW COVID-19 test detected the virus in only 85.2% of the samples that contained it. According to the director of the study a test should be at least 95% reliable. Abbott said the issue could have been caused by storing the samples in a special solution instead of inserting them directly into the testing machine.[201] Another study, by researchers at NYU Langone Medical Center, concluded that the machine was unacceptable in their clinical setting as it missed too many infections.[202] The FDA announced on May 14 that they have received and are reviewing 15 adverse event reports about the Abbott ID NOW device that suggest some users are receiving inaccurate negative results.[203]

Antibody test

Meanwhile, emerging evidence shows the unreliability of antibody tests for COVID-19, despite huge public funds to purchase these tests and the producers' claim of high sensitivity.[204] The Australian Therapeutic Goods Administration reported that serology antibody tests cannot used for COVID-19 diagnosis until the patient is symptomatic for at least 2 weeks and even so, it still needs to be further confirmed in a lab. The tests are invalid before the development of antibodies.[139]

Unusually, the regulator did not perform their own independent research to ensure the reliability of these test kits from the producers, some of which did not even have any experience of producing medical supplies, before the test kits were imported and used, due to relaxed regulation.[204][205] 80% of test kits for COVID-19 blood antibody that the Czech Republic purchased from China gave wrong results.[206][207] Slovakia purchased 1.2 million antibody-based test kits from China which were found to be inaccurate.[208] China accused the Czech Republic and Slovakia of incorrect use of antibody-based tests, after Slovakian Prime Minister said the kits should be "dumped into the Danube".[209] Ateş Kara of the Turkish Health Ministry said the antibody-based test kits Turkey purchased from China had a "high error rate" and did not "put them into use".[210][211] The UK purchased 3.5 million antibody test kits from China but in early April 2020 announced these were not usable.[212][213][214] On 21 April 2020, the Indian Council of Medical Research (ICMR) has advised Indian states to stop using the rapid antibody test kits purchased from China after receiving complaints from one state. Rajasthan health minister Raghu Sharma on 21 April said the kits gave only 5.4 percent accurate results against the expectation of 90 percent accuracy.[215] The Chinese embassy in India described the decision to oust Chinese test kits to be "unfair and irresponsible" and "look at issues with pre-emptive prejudice" when responding to ICMR's decision, and explained that antibody tests are only for "surveillance purposes".[216]

Confirmatory testing

The WHO recommends countries that do not have testing capacity and national laboratories with limited experience on COVID‑19 send their first five positives and the first ten negative COVID‑19 samples to one of the 16 WHO reference laboratories for confirmatory testing.[217][218] Out of the sixteen reference laboratories, seven are in Asia, five in Europe, two in Africa, one in North America and one in Australia.[219]

Clinical effectiveness

Testing, followed with quarantine of those who tested positive and tracing of those with whom the SARS-CoV-2 positive people had had contact, resulted in positive outcomes.[clarification needed].[citation needed]

Italy

Researchers working in the Italian town of , the site of the first COVID‑19 death in Italy, conducted two rounds of testing on the entire population of about 3,400 people, about ten days apart. About half the people testing positive had no symptoms, and all discovered cases were quarantined. With travel to the commune restricted, this eliminated new infections completely.[220]

Singapore

With aggressive contact tracing, inbound travel restrictions, testing, and quarantining, the COVID-19 pandemic in Singapore has proceeded much more slowly than in other developed countries[dubious ], but without extreme restrictions like forced closure of restaurants and retail establishments. Many events have been cancelled, and Singapore advised residents to stay at home on 28 March, but schools reopened on time after holiday break on 23 March,[221] even though schools did close moving to "full home-based learning" on 8 April.[222]

U.S. aircraft carrier

After 94% of the 4,800 crew had been tested, roughly 60 percent of the 600-plus sailors who tested positive did not have symptoms.[223] Sailors who test positive must spend at least two weeks in isolation and then test negative twice in a row, with the tests separated by at least a day. Five sailors who went through this process and had been admitted back onto the ship subsequently developed flu-like symptoms and again tested positive.[59]

Russia

On 27 April, Russia tested 3 million people and had 183,000 people under medical supervision because they were suspected of having the virus[224] with 87,147 people having tested positive for the virus and total confirmed deaths at 794.[225] On 28 April Anna Popova head of Federal Service for Surveillance in Healthcare (Roszdravnadzor) in a presidential update said there were now 506 laboratories testing and that 45% of those tested have no symptoms with the number having pneumonia reducing from 25% to 20% and only 5% of patients with a severe form. 40% of infections were from family members. The speed of people reporting illness has improved from six days to the day people find symptoms. Antibody testing was carried out on 3,200 Moscow doctors and 20% have immunity.[226]

Others

Several other countries, such as Iceland[227] and South Korea,[228] have also managed the pandemic with aggressive contact tracing, inbound travel restrictions, testing, and quarantining, but with less aggressive lock-downs. A statistical study has found that countries that have tested more, relative to the number of deaths, have much lower case fatality rates, probably because these countries are better able to detect those with only mild or no symptoms.[6] A subsequent study has also found that countries that have tested more widely also have a younger age distribution of cases, relative to the wider population.[229]

Research and development

A test which uses monoclonal antibodies which bind to the nucleocapsid protein (N protein) of the SARS-CoV-2 is being developed in Taiwan, with the hope that it can provide results in 15 to 20 minutes just like a rapid influenza test.[230] The World Health Organization raised concerns on 8 April that these tests need to be validated for the disease and are in a research stage only.[231] The United States Food and Drug Administration approved an antibody test on 2 April,[232] but some researchers warn that such tests should not drive public health decisions unless the percentage of COVID‑19 survivors who are producing neutralizing antibodies is also known.[48]

Virus testing statistics by country

The figures are influenced by the country's testing policy. If two countries are alike in every respect, including having the same spread of infection, and one of them has a shortage of testing capability, it may test only those showing symptoms while the other country having greater access to testing may test both those showing symptoms and others chosen at random. The country that tests only people showing symptoms will have a higher figure for "% (Confirmed cases as percentage of tested samples or tested cases)" than the country that also tests people chosen at random.[233] If two countries are alike in every respect, including which people they test, the one that tests more people will have a higher "Confirmed / million people".

COVID-19 testing statistics by country

Country Date[a] Tested Units[b] Confirmed
(cases)
% Tested /
million
people
Confirmed /
million
people
Ref.
Albania 23 May 13,133 samples 989 7.5 4,587 345 [234]
Argentina 23 May 125,893 samples 10,649 8.5 2,774 235 [235]
Armenia 24 May 50,397 6,661 13.2 17,074 2,257 [236]
Australia 26 May 1,289,436 samples 7,133 0.55 50,765 281 [237]
Austria 26 May 411,185 16,480 4.0 46,187 1,851 [238]
Azerbaijan 24 May 265,067 3,982 1.5 26,780 402 [239]
Bahrain 23 May 276,552 8,802 3.2 176,210 5,608 [240]
Bangladesh 24 May 243,636 samples 33,610 13.8 1,479 204 [241]
Barbados 23 May 4,664 92 2.0 16,249 321 [242]
Belarus 23 May 434,618 samples 35,244 8.1 45,789 3,713 [243]
Belgium 23 May 768,706 samples 56,810 7.4 66,752 4,933 [244]
Bhutan 23 May 15,293 samples 24 0.16 20,619 32 [245]
Bolivia 23 May 21,205 cases 5,915 27.9 1,855 518 [246]
Bosnia and Herzegovina 26 May 60,528 samples 2,416 4.0 17,690 706 [247]
Brazil 21 May 3,085,216 samples 291,579 9.5 14,681 1,387 [248][249]
Bulgaria 24 May 74,096 samples 2,427 3.3 10,661 349 [250]
Burkina Faso 21 May 6,642 samples 814 12.3 318 39 [251][252]
Cameroon 10 May 10,268 2,579 25.1 387 97 [253]
Canada 25 May 1,482,468 cases 85,711 5.8 39,121 2,262 [254]
Chile 23 May 457,332 samples 65,393 14.3 23,980 3,429 [255]
Colombia 21 May 222,210 samples 18,330 8.2 4,605 380 [256]
Costa Rica 23 May 22,910 samples 918 4.0 4,583 184 [257]
Croatia 24 May 61,482 cases 2,244 3.6 15,083 551 [258]
Cuba 22 May 92,629 1,931 2.1 8,178 170 [259]
Cyprus[c] 23 May 99,733 samples 927 0.93 115,530 1,074 [260]
Czechia 25 May 399,896 samples 8,955 2.2 37,395 837 [261]
Denmark 24 May 462,506 cases 11,558 2.5 78,006 1,949 [262]
DR Congo 5 May 2,256 705 31.3 25 7.9 [253]
Ecuador 6 May 81,392 samples 29,420 36.1 4,764 1,722 [263]
Egypt 5 May 90,000 samples 6,813 7.6 899 68 [253]
El Salvador 4 May 32,030 587 1.8 4,938 90 [264]
Estonia 16 May 68,840 samples 1,770 2.6 51,823 1,332 [265]
Ethiopia 26 May 87,264 samples 701 0.80 759 6.1 [266]
Finland 20 May 160,177 samples 6,493 4.1 28,896 1,171 [267]
France 3 May 831,174 samples 132,967 16.0 12,402 1,984 [268]
Germany 19 May 3,595,059 samples 176,007 4.9 43,236 2,117 [269]
Ghana 7 May 137,924 3,091 2.2 4,439 99 [270]
Greece 10 May 98,877 samples 4,015 4.1 9,182 373 [271]
Grenada 5 May 1,781 samples 21 10.3 1,570 162 [272]
Guinea 6 May 7,369 cases 1,856 25.2 561 141 [253]
Hungary 25 May 164,619 samples 3,756 2.3 17,041 389 [273]
Iceland 25 May 58,856 samples 1,804 3.1 161,577 4,953 [274]
India 27 May 3,242,160 samples 151,767 4.7 2,397 112 [275][276]
Indonesia 26 May 188,302 cases 23,165 21.3 703 87 [277]
Iran 23 May 781,286 samples 133,521 17.1 9,392 1,605 [278]
Iraq 7 May 120,604 samples 2,543 2.1 2,998 63 [279]
Ireland 25 May 325,795 samples 24,735 7.6 66,198 5,026 [280]
Israel 26 May 545,761 16,743 3.1 59,483 1,825 [281]
Italy 26 May 3,539,927 samples 230,555 6.5 58,647 3,820 [282]
Ivory Coast 25 May 18,303 2,423 13.2 694 92 [253]
Jamaica 12 May 7,465 samples 507 6.8 2,739 186 [283]
Japan 24 May 434,079 samples 16,251 3.8 3,441 131 [284]
Kazakhstan 12 May 422,011 samples 5,279 1.3 22,624 283 [285]
Kenya 10 May 32,097 samples 672 2.1 675 14 [286]
Kosovo 16 May 11,585 samples 978 8.4 6,399 540 [287]
Kyrgyzstan 5 May 58,030 samples 843 1.5 9,082 132 [288]
Latvia 22 May 96,366 samples 1,030 1.0 50,191 536 [289]
Lebanon 12 May 53,269 870 1.6 7,804 127 [290]
Lithuania 26 May 275,058 samples 1,639 0.60 98,434 587 [291]
Luxembourg 25 May 68,107 samples 3,993 5.9 108,778 6,377 [292]
Malawi 5 May 961 samples 41 4.3 50 2.1 [293]
Malaysia 26 May 519,944 cases 7,604 1.5 15,865 232 [294]
Maldives 22 May 17,174 samples 1,274 7.4 43,758 3,246 [295]
Malta 14 May 45,967 samples 522 1.1 93,134 1,058 [296]
Mauritius 21 May 98,075 samples 332 0.34 77,469 262 [297]
Mexico 11 May 114,125 cases 36,327 31.8 887 282 [298]
Montenegro 5 May 8,534 samples 324 3.8 13,520 513 [299]
Morocco 11 May 67,741 cases 6,226 9.2 1,835 169 [300]
Mozambique 10 May 3,923 91 2.3 126 2.9 [301]
Myanmar 6 May 9,980 samples 161 1.6 183 3.0 [302]
Nepal 25 May 138,841 603 0.43 4,942 21 [303]
Netherlands 5 May 306,460 cases 44,447 14.5 17,587 2,551 [304]
New Zealand 26 May 267,435 samples 1,154 0.43 53,663 232 [305]
Nigeria 17 May 33,970 samples 5,621 16.5 166 27 [306]
North Korea 17 April 740 cases 0 0 29 0 [307]
North Macedonia 5 May 17,544 1,526 8.7 8,446 735 [308]
Northern Cyprus[d] 23 May 31,005 108 0.35 95,107 331 [309]
Norway 20 May 223,045 cases 8,268 3.7 41,554 1,540 [310]
Oman 20 May 72,000 samples 5,671 7.9 15,493 1,220 [311]
Pakistan 26 May 499,399 59,151 11.8 2,306 273 [312]
Palestine 7 May 34,511 samples 547 1.6 6,831 108 [313]
Panama 6 May 38,014 7,731 20.3 9,101 1,851 [314]
Paraguay 7 May 13,096 samples 462 3.5 1,836 65 [315]
Peru 26 May 875,721 samples 129,751 14.8 26,679 3,953 [316]
Philippines 25 May 307,434 samples 14,319 4.7 3,044 142 [317]
Poland 22 May 719,571 samples 20,379 4.0 18,746 531 [318]
Portugal 23 May 689,705 samples 30,471 4.4 67,114 2,965 [319]
Qatar 23 May 184,794 cases 42,213 22.8 64,141 14,652 [320]
Romania 25 May 377,191 samples 18,283 4.8 19,441 942 [321]
Russia 25 May 9,160,590 samples 362,342 4.0 62,425 2,469 [322][323]
Rwanda 7 May 38,834 271 0.70 2,998 21 [324]
Saint Lucia 25 May 898 18 2.0 4,937 99 [325]
Saudi Arabia 8 May 418,722 35,432 8.5 12,027 1,018 [326]
Senegal 11 May 22,481 1,886 8.4 1,418 119 [327]
Serbia 10 May 140,592 cases 10,114 7.2 20,189 1,452 [328]
Singapore 18 May 294,414 samples 28,343 9.6 51,619 4,969 [329][330]
Slovakia 25 May 160,523 samples 1,513 0.94 29,411 277 [331]
Slovenia 15 May 70,220 samples 1,465 2.1 33,533 700 [332]
South Africa 23 May 564,370 cases 21,343 3.8 9,602 363 [333]
South Korea 25 May 807,348 cases 11,206 1.4 15,613 217 [334]
Spain 21 May 3,556,567 samples 235,290 6.6 76,104 5,035 [335][336]
Sri Lanka 24 May 53,092 cases 1,094 2.1 2,450 50 [337]
Sudan 9 May 1,747 samples 1,164 66.6 40 27 [253]
Sweden 13 May 177,200 cases 27,909 15.8 17,158 2,702 [338]
Switzerland[e] 25 May 372,146 samples 30,746 8.3 43,229 3,572 [339]
Taiwan[f] 27 May 71,405 cases 441 0.62 3,025 19 [340]
Tanzania 29 April 652 480 73.6 11 8.0 [253]
Thailand 7 May 89,791 cases 2,992 3.3 1,293 43 [341]
Trinidad and Tobago 9 May 2,271 samples 116 5.1 1,665 85 [342]
Tunisia 9 May 32,818 cases 1,032 3.1 2,777 87 [343]
Turkey 23 May 1,807,673 cases 155,686 8.6 21,739 1,872 [344]
Uganda 15 May 70,117 samples 203 0.29 1,533 4.4 [345]
Ukraine 23 May 277,712 samples 20,580 7.4 6,607 490 [346]
United Arab Emirates 22 May 1,924,234 27,892 1.4 200,455 2,906 [347]
United Kingdom 26 May 3,681,295 samples 265,227 7.2 54,501 3,927 [348]
United States 25 May 14,604,942 1,654,829 11.3 44,495 5,042 [349][350]
Uruguay 9 May 39,469 samples 958 2.4 11,373 276 [351]
Uzbekistan 7 May 371,000 samples 2,298 0.62 10,900 68 [352]
Venezuela 25 May 832,526 samples 1177 0.14 28,820 41 [353]
Vietnam 25 May 261,004 samples 325 0.12 2,644 3.3 [354]
Zimbabwe 10 May 8,244 34 0.41 555 2.3 [355]
  1. ^ Local time.
  2. ^ For some countries it is unclear whether they report samples or cases. One person tested twice is recorded as one case and two samples.
  3. ^ Excluding Northern Cyprus.
  4. ^ Northern Cyprus is not recognized as a sovereign state by any country except Turkey.
  5. ^ Includes data for Liechtenstein.
  6. ^ The UN does not recognize Taiwan as a sovereign state.

Virus testing statistics by country subdivision

COVID-19 testing statistics by country subdivision

Country[a] Subdivision Date[b] Tested Confirmed
(cases)
% Tested /
million
people
Confirmed /
million
people
Ref.
Australia Australian Capital Territory 27 May 15,253 107 0.70 38,019 251 [356]
Australia New South Wales 27 May 464,351 3,089 0.67 57,402 382 [356]
Australia Northern Territory 22 May 7,369 29 0.39 29,971 118 [356]
Australia Queensland 27 May 180,371 1,058 0.59 35,401 208 [356]
Australia South Australia 27 May 91,597 440 0.48 52,291 251 [356]
Australia Tasmania 27 May 25,644 228 0.89 47,997 427 [356]
Australia Victoria 27 May 471,000 1,618 0.34 71,420 245 [356]
Australia Western Australia 27 May 78,308 570 0.73 29,869 217 [356]
Canada Alberta 25 May 239,799 6,879 2.9 54,337 1,559 [357]
Canada British Columbia 25 May 135,190 2,530 1.9 26,451 495 [358]
Canada Manitoba 26 May 39,321 292 0.74 28,545 212 [359]
Canada New Brunswick 25 May 22,572 121 0.54 28,939 155 [360]
Canada Newfoundland and Labrador 25 May 11,347 260 2.3 21,764 499 [361]
Canada Northwest Territories 25 May 2,113 5 0.24 47,056 111 [362]
Canada Nova Scotia 25 May 39,509 1,051 2.7 40,420 1,075 [363]
Canada Nunavut 21 May 749 0 0 19,157 0 [364]
Canada Ontario 24 May 619,539 25,904 4.2 42,112 1,761 [365]
Canada Prince Edward Island 22 May 5,356 27 0.50 33,865 171 [366]
Canada Quebec 24 May 389,618 47,984 12.3 45,635 5,620 [367]
Canada Saskatchewan 25 May 44,312 634 1.4 37,500 537 [368]
Canada Yukon 22 May 1,140 11 0.96 27,752 268 [369]
China Guangdong 13 May 6,790,000 2,099 0.03 65,099 20 [370]
China Hong Kong 27 April 154,989 1,037 0.67 20,714 139 [371]
China Wuhan, Hubei 13 May 2,637,964 52,141 2.0 235,280 4,650 [372][373]
India Andaman and Nicobar Islands 23 May 7,327 33 0.45 18,456 83 [374]
India Andhra Pradesh 26 May 322,714 2,983 0.92 6,180 57 [375][376]
India Arunachal Pradesh 26 May 6,319 2 0.03 4,201 1.3 [377]
India Assam 26 May 72,654 682 0.94 2,119 20 [378]
India Bihar 25 May 66,148 2,968 4.5 553 25 [379]
India Chandigarh 26 May 4,207 278 6.6 3,568 236 [380]
India Chhattisgarh 26 May 57,479 360 0.63 2,001 13 [381]
India Delhi 26 May 178,579 14,465 8.1 9,013 730 [382]
India Goa 25 May 12,860 67 0.52 8,351 44 [383]
India Gujarat 26 May 189,313 14,821 7.8 2,787 218 [384][385]
India Haryana 26 May 102,018 1,305 1.3 3,558 46 [386]
India Himachal Pradesh 25 May 28,346 223 0.79 3,883 31 [387]
India Jammu and Kashmir 25 May 134,188 1,668 1.2 10,163 126 [388]
India Jharkhand 25 May 50,709 405 0.80 1,356 11 [389]
India Karnataka 26 May 228,914 2,283 1.00 3,479 35 [390]
India Kerala 25 May 54,899 963 1.8 1,563 27 [391][392]
India Madhya Pradesh 25 May 138,584 6,859 4.9 1,685 83 [393]
India Maharashtra 25 May 378,555 54,758 14.5 3,099 448 [394]
India Meghalaya 25 May 6,553 15 0.23 2,033 4.7 [395]
India Odisha 25 May 127,776 1,438 1.1 2,926 33 [396][397]
India Puducherry 25 May 6,606 43 0.65 4,392 29 [398]
India Punjab 26 May 69,818 2,106 3.0 2,360 71 [399]
India Rajasthan 26 May 337,159 7,536 2.2 4,364 98 [400][401]
India Tamil Nadu 25 May 421,450 17,082 4.1 5,568 226 [402][403]
India Tripura 25 May 20,871 198 0.95 5,228 50 [404]
India Uttar Pradesh 26 May 240,588 6,724 2.8 1,069 30 [405]
India Uttarakhand 26 May 23,076 400 1.7 2,071 36 [406]
India West Bengal 26 May 157,277 4,009 2.5 1,623 41 [407]
Italy Abruzzo 26 May 68,733 3,230 4.7 52,405 2,463 [282]
Italy Aosta Valley 26 May 14,262 1,181 8.3 113,491 9,398 [282]
Italy Apulia 26 May 106,873 4,469 4.2 26,526 1,109 [282]
Italy Basilicata 26 May 27,197 399 1.5 48,319 709 [282]
Italy Calabria 26 May 64,514 1,157 1.8 33,133 594 [282]
Italy Campania 26 May 179,845 4,767 2.7 30,999 822 [282]
Italy Emilia-Romagna 26 May 297,854 27,611 9.3 66,791 6,192 [282]
Italy Friuli-Venezia Giulia 26 May 121,412 3,251 2.7 99,909 2,675 [282]
Italy Lazio 26 May 238,967 7,661 3.2 40,647 1,303 [282]
Italy Liguria 26 May 96,678 9,550 9.9 62,347 6,159 [282]
Italy Lombardy 26 May 685,058 87,417 12.8 68,093 8,689 [282]
Italy Marche 26 May 97,285 6,718 6.9 63,782 4,404 [282]
Italy Molise 26 May 13,452 432 3.2 44,016 1,414 [282]
Italy Piedmont 26 May 293,473 30,314 10.3 67,366 6,958 [282]
Italy Sardinia 26 May 51,968 1,354 2.6 31,696 826 [282]
Italy Sicilia 26 May 137,682 3,430 2.5 27,537 686 [282]
Italy South Tyrol 26 May 61,464 2,593 4.2 115,306 4,864 [282]
Italy Trentino 26 May 81,149 4,415 5.4 149,893 8,155 [282]
Italy Tuscany 26 May 234,796 10,070 4.3 62,954 2,700 [282]
Italy Umbria 26 May 65,013 1,431 2.2 73,710 1,622 [282]
Italy Veneto 26 May 602,252 19,105 3.2 122,762 3,894 [282]
Japan Tokyo 19 May 14,464 5,070 35.1 1,038 364 [408]
Russia Moscow 20 May 1,853,074 152,306 8.2 146,164 12,013 [409][410]
Russia Moscow Oblast 26 May 366,201 35,163 9.6 47,615 4,572 [411]
Russia Nizhny Novgorod Oblast 20 May 173,981 7,209 4.1 53,785 2,229 [409][410]
Russia Saint Petersburg 20 May 558,716 11,795 2.1 103,503 2,185 [409][410]
South Africa Flag of the Western Cape Province.png Western Cape 23 May 114,869 12,947 11.3 16,783 1,892 [412]
United Kingdom Scotland 24 May 101,713 15,101 14.8 18,704 2,777 [413]
United States California 26 May 1,696,396 96,733 5.7 42,933 2,448 [414]
United States Florida 26 May 924,920 52,255 5.6 43,064 2,433 [415]
United States Illinois 26 May 786,794 113,195 14.4 62,090 8,933 [416]
United States Louisiana 26 May 341,026 38,054 11.2 73,358 8,186 [417]
United States Massachusetts 26 May 545,481 93,693 17.2 78,492 13,482 [418]
United States Michigan 26 May 495,416 55,104 11.1 49,440 5,499 [419]
United States New Jersey 26 May 635,892 155,764 24.5 71,592 17,537 [420]
United States New York 26 May 1,774,128 363,836 20.5 91,198 18,703 [421]
United States Texas 26 May 858,398 56,560 6.6 29,604 1,951 [422]
United States Washington 25 May 330,598 20,065 6.1 43,415 2,635 [423]
  1. ^ To sort within countries, click the column you want to sort by, then click the Country column.
  2. ^ Local time.

References

 This article incorporates public domain material from the Centers for Disease Control and Prevention document: "Symptom-Based Strategy to Discontinue Isolation for Persons with COVID-19". Retrieved 5 May 2020.

  1. ^ "Test for Past Infection – CDC". CDC.gov. Centers for Disease Control and Prevention. 11 February 2020. Archived from the original on 16 May 2020. Retrieved 19 May 2020. Antibody blood tests, also called antibody tests, check your blood by looking for antibodies, which show if you had a previous infection with the virus. Depending on when someone was infected and the timing of the test, the test may not find antibodies in someone with a current COVID-19 infection.
  2. ^ a b Abbasi, Jennifer (17 April 2020). "The Promise and Peril of Antibody Testing for COVID-19". JAMA. JAMA Network. 323 (19): 1881. doi:10.1001/jama.2020.6170. PMID 32301958. Retrieved 20 April 2020.
  3. ^ Ioannidis, John P.A. (17 March 2020). "A fiasco in the making? As the coronavirus pandemic takes hold, we are making decisions without reliable data". STAT. Retrieved 22 March 2020.
  4. ^ "Total tests for COVID-19 per 1,000 people". Our World in Data. Archived from the original on 18 May 2020. Retrieved 16 April 2020.
  5. ^ "Iceland has tested more of its population for coronavirus than anywhere else. Here's what it learned". USA Today. 11 April 2020. Archived from the original on 28 April 2020. Retrieved 16 April 2020.
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